Morphological Changes in Betulin Particles as a Result of Polymorphic Transformations, and Formation of Co-Crystals under Heating

Changes in the morphology of betulin crystals during heating at selected temperatures corresponding to polymorphic transformations were investigated. It was shown that prismatic starting form III converted into needles 120 °C after water removal, followed by III→II transformation. During further up 180 °C, whiskers I grown. Experiments on presence dicarboxylic acids, adipic or suberic showed morphological changes can serve as a test for formation cocrystals. According changes, cocrystals with acid under identified. The interaction vapor surface suggested. In contrast, mixture and provided only evidence components. results cocrystal compared preparation liquid-assistance grinding method. Despite fact forms high area formed when heated, dissolution studies polymorph exhibited highest rate comparison polymorphs obtained heating.